.Nature Medicine, Released online: thirteen September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized stage 3b/4 DESTINY-Breast12 research, trastuzumab deruxtecan (T-DXd) procedure of clients with HER2+ enhanced bosom cancer and energetic or stable human brain metastases presented constant intracranial task and systemic efficacy of T-DXd.